Description

Ethyl (2E)-3-Pyrimidin-5-Ylacrylate is a high-purity, specialized acrylate ester derivative featuring a pyrimidine heterocycle, serving as a critical building block in advanced organic synthesis. This compound is valued for its role as a Michael acceptor and a versatile intermediate for constructing complex molecular architectures with potential biological activity. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule drug candidates.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Monomer or cross-linker for creating functional polymers with tailored electronic or photophysical properties.
• Chemical Biology: Used in the development of molecular probes and bioconjugation reagents targeting biological systems.
• Academic & Contract Research: Essential for methodological development and discovery chemistry in university and CRO laboratories.

Basic Information

Product Name	Ethyl (2E)-3-Pyrimidin-5-Ylacrylate
CAS No.	123530-61-0
Molecular Formula	C9H10N2O2
Molecular Weight	178.19 g/mol
Synonyms	Ethyl (E)-3-(pyrimidin-5-yl)acrylate; (E)-Ethyl 3-(pyrimidin-5-yl)acrylate; 5-Pyrimidineacrylic acid ethyl ester, (E)-; 2-Propenoic acid, 3-(5-pyrimidinyl)-, ethyl ester, (2E)-; Ethyl 3-(5-pyrimidinyl)-2-propenoate; 123530-61-0; NSC 405124
EINECS	Contact for details

Quality Control

Our Ethyl (2E)-3-Pyrimidin-5-Ylacrylate is manufactured under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.