Description

3-(2-(Trifluoromethyl)Phenyl)Acrylaldehyde is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the acrylaldehyde moiety combined with the electron-withdrawing and lipophilicity-enhancing properties of the ortho-trifluoromethyl group. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in medicinal chemistry for lead optimization and the development of novel active ingredients.

Application

• Pharmaceutical Intermediates: A key precursor in the synthesis of novel drug candidates, especially those targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group often enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored optical or surface properties.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Studies: An important substrate for investigating new fluorination methodologies and the influence of fluorine on reaction pathways.
• Chemical Library Production: Used in high-throughput and combinatorial chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	3-(2-(Trifluoromethyl)Phenyl)Acrylaldehyde
CAS No.	123486-66-8
Molecular Formula	C10H7F3O
Molecular Weight	200.16 g/mol
Synonyms	2-(Trifluoromethyl)cinnamaldehyde; (E)-3-[2-(Trifluoromethyl)phenyl]prop-2-enal; 3-(2-Trifluoromethylphenyl)-2-propenal; α-(2-Trifluoromethylphenyl)acrolein; (E)-3-(2-(Trifluoromethyl)phenyl)acrylaldehyde; 2-Trifluoromethylcinnamaldehyde; (E)-2-(Trifluoromethyl)cinnamaldehyde
EINECS	Contact for details

Quality Control

Our 3-(2-(Trifluoromethyl)Phenyl)Acrylaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider under an inert atmosphere (e.g., nitrogen or argon). Keep away from heat, sparks, and open flame. Isolate from incompatible materials such as strong bases, reducing agents, and peroxides.

Specification

Item	Specification
Appearance	Yellow to light brown liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.