Description

Boc-Glu(Ofm)-Oh CAS NO 123417-18-5 is a protected amino acid derivative, specifically N-tert-butoxycarbonyl-glutamic acid γ-2,4-dimethoxybenzyl ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of glutamic acid while protecting its reactive side chain. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled introduction of glutamic acid residues into peptide chains.
• Pharmaceutical Research: Synthesis of peptide drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Used to create peptide-protein or peptide-small molecule conjugates for targeted drug delivery systems.
• Combinatorial Chemistry: Serves as a building block in libraries for high-throughput screening of bioactive peptides.
• Peptide Vaccine Development: Critical for constructing antigenic peptide sequences.
• Biochemical Research: Synthesis of substrates, inhibitors, and standards for enzymatic and metabolic studies.

Basic Information

Product Name	Boc-Glu(Ofm)-Oh
CAS No.	123417-18-5
Molecular Formula	C19H27NO8
Molecular Weight	397.42 g/mol
Synonyms	N-α-Boc-L-glutamic acid 5-(2,4-dimethoxybenzyl) ester; N-(tert-Butoxycarbonyl)-L-glutamic acid γ-(2,4-dimethoxybenzyl) ester; Boc-Glu(ODmb)-OH; Boc-L-Glu(ODmb)-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]pentanedioic acid 5-(2,4-dimethoxybenzyl) ester; Boc-Glu(O-2,4-Dimethoxybenzyl)-OH; N-Boc-L-glutamic acid γ-(2,4-dimethoxybenzyl) ester
EINECS	Contact for details

Quality Control

Our Boc-Glu(Ofm)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.