Description

Substance P (6-11), Glu(6)- CAS NO 123067-53-8 is a specific, biologically active fragment of the neuropeptide Substance P, modified with a glutamic acid residue at position 6. This synthetic peptide is a critical research tool for investigating the structure-activity relationships and signaling pathways of the Substance P receptor, particularly the NK1 subtype. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, pain management, and inflammation studies.

Application

• Neuroscience Research: A key ligand for studying the role of Substance P in neurotransmission, neurogenic inflammation, and pain signaling pathways.
• Receptor Binding Assays: Used in competitive binding studies to characterize and quantify NK1 receptor affinity and distribution.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in the screening and development of novel NK1 receptor antagonists for pain, migraine, and psychiatric disorders.
• Cell Signaling Studies: Employed to activate specific intracellular cascades in vitro to model physiological and pathophysiological processes.
• Biochemical Tool: Utilized in enzymatic stability studies and to investigate peptide metabolism.

Basic Information

Product Name	Substance P (6-11), Glu(6)-
CAS No.	123067-53-8
Molecular Formula	C36H58N12O10S
Molecular Weight	851.0 g/mol
Synonyms	Substance P Fragment 6-11, [Glu6]-Substance P (6-11); Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (Gln6 variant); SP (6-11), Glu6; Neurokinin-1 Receptor Ligand Fragment; H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2; Tachykinin Fragment
EINECS	Contact for details

Quality Control

Our Substance P (6-11), Glu(6)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, ensuring the material meets the stringent requirements for life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.