Description

4-(3,5-Bis(Trifluoromethyl)-1H-Pyrazol-1-Yl)-Phenylamine is a high-value, fluorinated aromatic amine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring a pyrazole core flanked by trifluoromethyl groups, is engineered to impart exceptional electronic properties, metabolic stability, and lipophilicity to final compounds. This specialty intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases, where the trifluoromethyl groups enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in developing next-generation herbicides, fungicides, and insecticides, where its structural motifs contribute to improved pest selectivity and environmental persistence profiles.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Catalyst Ligand Precursor: The amine and heterocyclic functionalities make it a valuable starting material for designing novel ligands used in transition metal catalysis for fine chemical production.
• Chemical Biology & Proteomics: Employed as a tagging or labeling reagent in probe development for studying enzyme mechanisms and protein interactions.

Basic Information

Product Name	4-(3,5-Bis(Trifluoromethyl)-1H-Pyrazol-1-Yl)-Phenylamine
CAS No.	123066-64-8
Molecular Formula	C12H6F6N3
Molecular Weight	306.19 g/mol
Synonyms	1-[4-Aminophenyl]-3,5-bis(trifluoromethyl)pyrazole; 4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]aniline; 1-(4-Aminophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole; 4-(3,5-Bis(trifluoromethyl)pyrazol-1-yl)phenylamine; 4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)benzenamine; AN-968/34224036 (common vendor code); Bis(trifluoromethyl)pyrazole aniline derivative
EINECS	Contact for details

Quality Control

Every batch of 4-(3,5-Bis(Trifluoromethyl)-1H-Pyrazol-1-Yl)-Phenylamine is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and GC-MS, to ensure compliance with exacting customer specifications and industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.