Description

D-Proline, 2-Methyl-, Hydrochloride is a high-purity, non-natural amino acid derivative widely utilized in advanced pharmaceutical research and synthesis. This chiral building block is essential for the development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs) where stereochemical control is critical. It serves as a key intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug candidates, particularly protease inhibitors and other bioactive peptides.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce constrained proline analogs, influencing peptide backbone conformation and stability.
• Asymmetric Synthesis: Employed as a catalyst or chiral auxiliary in stereoselective organic transformations to induce enantioselectivity.
• Biochemical Research: Serves as a standard or reagent in metabolic pathway studies and enzyme-substrate interaction investigations.
• Agrochemical Development: A potential building block for creating novel, chiral active ingredients with specific biological activity.
• Material Science: Exploration of its use in constructing functionalized organic frameworks and advanced polymeric materials.

Basic Information

Product Name	D-Proline, 2-Methyl-, Hydrochloride
CAS No.	123053-48-5
Molecular Formula	C6H11NO2 • HCl
Molecular Weight	165.62 g/mol (Free base: 129.16)
Synonyms	(2R)-2-Methylpyrrolidine-2-carboxylic acid hydrochloride; D-2-Methylproline hydrochloride; (R)-2-Methylproline HCl; D-α-Methylproline hydrochloride; (2R)-2-Methylproline hydrochloride; D-2-Pipecolinic acid hydrochloride (context-specific); H-D-2-MePro-OH • HCl
EINECS	Contact for details

Quality Control

Our D-Proline, 2-Methyl-, Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC, chiral analysis, and NMR to ensure identity, purity, and enantiomeric excess meet stringent specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.