Description

Dihydrexidine Hydrochloride is a high-purity, small-molecule chemical compound of significant interest in advanced pharmaceutical research and development. This compound serves as a potent and selective full agonist for dopamine D1 receptors, making it a critical tool for neurological studies. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in neuroscience, psychopharmacology, and the development of novel central nervous system (CNS) therapeutics.

Application

• Neuroscience Research: As a key pharmacological tool for studying dopamine D1 receptor signaling pathways, function, and distribution in the brain.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and in vitro assays to identify and characterize new compounds targeting dopaminergic systems.
• Preclinical Studies: Employed in animal models to investigate the role of D1 receptors in cognition, motor control, reward, and potential therapeutic applications for disorders like Parkinson's disease.
• Biochemical Research: Utilized in receptor binding assays and functional studies to understand G-protein coupling and downstream cellular effects.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Academic Research: Fundamental research in universities and institutes exploring neuropharmacology and behavioral neuroscience.

Basic Information

Product Name	Dihydrexidine Hydrochloride
CAS No.	123039-93-0
Molecular Formula	C16H17NO3 • HCl
Molecular Weight	307.77 g/mol (Free base: 271.31 g/mol)
Synonyms	(±)-Dihydrexidine Hydrochloride; trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine Hydrochloride; A-77636 Hydrochloride; DHX HCl; 5,6,6a,7,8,12b-Hexahydrobenzo[a]phenanthridine-10,11-diol Hydrochloride; LY-163502 (Hydrochloride); D1 Dopamine Receptor Agonist
EINECS	Contact for details

Quality Control

Our Dihydrexidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.