Description

Cholecystokinin 33 (10-20) CAS NO 122998-75-8 is a specific, biologically active fragment of the cholecystokinin (CCK) peptide hormone. This high-purity synthetic peptide is critical for research into gastrointestinal and neurological functions, serving as a precise tool for receptor binding studies and signal pathway analysis. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on metabolic disorders, appetite regulation, and central nervous system research.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of CCK receptor subtypes (CCKA and CCKB).
• Pharmacological Assays: Employed in competitive binding assays and functional studies to screen and characterize novel therapeutic compounds.
• Neuroscience Studies: Investigation of CCK's role as a neurotransmitter/neuromodulator in anxiety, satiety, and pain perception pathways.
• Gastrointestinal Physiology: Research on pancreatic enzyme secretion, gallbladder contraction, and gut motility.
• Cell Signaling Research: Tool for activating intracellular signaling cascades (e.g., phospholipase C, inositol trisphosphate) in vitro.
• Antibody Production: Can serve as an antigen for generating specific anti-CCK antibodies for immunoassays.

Basic Information

Product Name	Cholecystokinin 33 (10-20)
CAS No.	122998-75-8
Molecular Formula	C58H83N15O16S
Molecular Weight	1270.43 g/mol
Synonyms	CCK-33 (10-20); Cholecystokinin Fragment 10-20; CCK (10-20); H-Val-Lys-Asn-Asn-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2; Sincalide fragment (10-20); CCK Octapeptide fragment; CCK-8 related fragment; Asp-Tyr(SO3)-Met-Gly-Trp-Met-Asp-Phe-NH2 (sequence variant)
EINECS	Contact for details

Quality Control

Every batch of Cholecystokinin 33 (10-20) is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results for HPLC purity, amino acid analysis, mass spectrometry (MS), and other relevant tests.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Within ±10% of theoretical values
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.