Description

5-Pyrimidineacetic Acid, -α-,2-Bis(1,1-Dimethylethyl)-, (+)- (9Ci) is a high-purity, chiral pyrimidine derivative characterized by its tert-butyl substituents and acetic acid moiety. This compound serves as a sophisticated building block and key chiral intermediate in advanced organic synthesis, where its specific stereochemistry and functional groups are critical for directing reactions. It is primarily utilized by pharmaceutical R&D and fine chemical sectors for developing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for targeted therapies.
• Agrochemical Synthesis: Used in creating advanced, high-specificity active ingredients for crop protection products.
• Ligand and Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialized organic compounds for advanced materials, such as liquid crystals or organic semiconductors.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic chemistry and process development in fine chemical manufacturing.

Basic Information

Item	Detail
Product Name	5-Pyrimidineacetic Acid, -α-,2-Bis(1,1-Dimethylethyl)-, (+)- (9Ci)
CAS No.	122936-60-1
Molecular Formula	C14H22N2O2
Molecular Weight	250.34 g/mol
Synonyms	(+)-α,2-Di-tert-butyl-5-pyrimidineacetic acid; (R)-α,2-Di-tert-butylpyrimidine-5-acetic acid; 5-Pyrimidineacetic acid, α,2-bis(1,1-dimethylethyl)-, (αR)-; 122936-60-1; (R)-2,5-Di-tert-butyl-pyrimidine-4-acetic acid; α,2-Di-tert-butyl-5-pyrimidineacetic acid (enantiomer); (R)-α,2-Di-tert-butyl-5-pyrimidineacetic acid
EINECS	Contact for details

Quality Control

Our production of 5-Pyrimidineacetic Acid, -α-,2-Bis(1,1-Dimethylethyl)-, (+)- (9Ci) adheres to stringent quality management protocols. Each batch is analyzed to ensure high chemical purity and enantiomeric excess, critical for its application in chiral synthesis. Comprehensive testing includes identity confirmation, assay, and impurity profiling. A Certificate of Analysis (COA) documenting all relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.