Description

5-Pyrimidineacetic Acid, -α-,2-Bis(1,1-Dimethylethyl)-, (-)- (9Ci) is a high-purity, chiral pyrimidine derivative of significant interest in advanced organic synthesis. This compound serves as a sophisticated building block, valued for its sterically hindered structure and defined stereochemistry, which are critical for constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the creation of advanced, high-efficacy crop protection agents and pesticides.
• Ligand and Catalyst Development: Serves as a precursor for designing specialized ligands in asymmetric catalysis and organometallic chemistry.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic and R&D: A valuable reagent for methodological studies in organic synthesis and stereochemistry at universities and corporate R&D laboratories.

Basic Information

Product Name	5-Pyrimidineacetic Acid, -α-,2-Bis(1,1-Dimethylethyl)-, (-)- (9Ci)
CAS No.	122936-59-8
Molecular Formula	C14H22N2O2
Molecular Weight	250.34 g/mol
Synonyms	(-)-α,2-Di-tert-butyl-5-pyrimidineacetic acid; (S)-α,2-Di-tert-butylpyrimidine-5-acetic acid; 2,2-Dimethyl-1-[(5-pyrimidinyl)methyl]propanoic acid, 1,1-dimethylethyl ester (related); 5-Pyrimidineacetic acid, α,2-bis(1,1-dimethylethyl)-, (-)-; tert-Butyl 2-tert-butyl-5-pyrimidineacetate (precursor); α-(tert-Butyl)-2-(tert-butyl)-5-pyrimidineacetic acid
EINECS	Contact for details

Quality Control

Every batch of 5-Pyrimidineacetic Acid, -α-,2-Bis(1,1-Dimethylethyl)-, (-)- (9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the identity, purity, and enantiomeric excess meet the rigorous demands of research and development. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and related substances are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat sources and incompatible materials. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.