Description

Boc-Trp-Nhme is a protected amino acid derivative, specifically N-Boc-N'-methyl-L-tryptophanamide, widely used as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptides with specific tryptophan residues. It is particularly valuable for the pharmaceutical, biotechnology, and life sciences industries engaged in the development of therapeutic peptides, research biochemicals, and novel active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of tryptophan into peptide chains, especially where N-methylation is required.
• Pharmaceutical Research: Used in the research and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Combinatorial Chemistry: Serves as a building block in libraries for drug discovery and high-throughput screening of bioactive compounds.
• Bioconjugation: Can be utilized in the synthesis of peptide tags, probes, or linkers for bioconjugation applications.
• Academic & Industrial R&D: Fundamental reagent for studying peptide structure-activity relationships (SAR) and developing novel synthetic methodologies.

Basic Information

Product Name	Boc-Trp-Nhme
CAS No.	122900-21-4
Molecular Formula	C₁₉H₂₅N₃O₃
Molecular Weight	343.42 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-N'-methyl-L-tryptophanamide; Boc-L-Tryptophan-N'-methylamide; Nα-Boc-N'-methyl-L-tryptophanamide; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1H-indol-3-yl)-N-methylpropanamide; Boc-Trp-NHMe; Boc-Tryptophan-N-methylamide; tert-Butyloxycarbonyl-L-tryptophan N-methylamide
EINECS	Contact for details

Quality Control

Our Boc-Trp-Nhme is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, chiral purity, and impurity profiles. While produced to meet high-grade standards, specific compliance with pharmacopeial monographs (e.g., USP, EP) can be discussed based on project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.