Description

Endothelin (16-21) Amide is a synthetic peptide fragment derived from the potent vasoconstrictor endothelin-1. This compound is a critical research tool for studying endothelin receptor binding, signal transduction pathways, and cardiovascular physiology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cardiovascular disease, hypertension, and novel therapeutic discovery.

Application

• Biomedical Research: A key reagent for investigating the structure-activity relationship (SAR) of endothelin peptides and their interaction with ETA and ETB receptors.
• Pharmacological Studies: Used in competitive binding assays and functional studies to screen and characterize potential endothelin receptor antagonists.
• Cardiovascular Research: Employed in models to understand the role of endothelin in vasoconstriction, blood pressure regulation, and related pathologies.
• Peptide Chemistry Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in peptide synthesis.
• Academic & Institutional Labs: Fundamental tool for graduate and post-doctoral research in molecular biology, physiology, and medicinal chemistry departments.

Basic Information

Product Name	Endothelin (16-21) Amide
CAS No.	122855-39-4
Molecular Formula	C34H51N9O9S2
Molecular Weight	793.96 g/mol
Synonyms	Endothelin-1 (16-21), amide; H-Cys-Val-Tyr-Phe-Cys-His-OH (Disulfide bridge: Cys1-Cys15); ET-1 (16-21); [Cys1,15]-Endothelin-1(16-21); Endothelin-1 hexapeptide (16-21); CVYFCH-NH2 (cyclic); Cyclo(1-15)[Cys-Val-Tyr-Phe-Cys-His] amide
EINECS	Contact for details

Quality Control

Our Endothelin (16-21) Amide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided to ensure compliance with research-grade specifications and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.