Description

4-Bromo-D-Phenylalanine Hydrochloride is a halogenated, non-natural amino acid derivative of significant interest in advanced pharmaceutical research and development. Its core value lies in serving as a critical chiral building block for the synthesis of complex bioactive molecules, particularly peptide-based drugs and enzyme inhibitors. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require precise stereochemistry and reliable quality for their synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic peptides and peptidomimetics.
• Protease Inhibitor Development: Used in the synthesis of compounds designed to target specific enzymes like proteases, which are relevant in virology and oncology.
• Bioconjugation & Labeling: The bromine moiety provides a handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira) for creating labeled probes or antibody-drug conjugates (ADCs).
• Metabolic Studies: Employed as a stable, non-metabolizable analog of phenylalanine in biochemical and pharmacological research to study amino acid transport and metabolism.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in asymmetric catalytic processes to induce chirality in target molecules.
• Material Science Research: Can be incorporated into novel polymers or supramolecular structures to impart specific chemical functionality.

Basic Information

Product Name	4-Bromo-D-Phenylalanine Hydrochloride
CAS No.	122852-33-9
Molecular Formula	C9H11BrNO2 • HCl
Molecular Weight	282.55 g/mol (Free base: 244.10)
Synonyms	(R)-2-Amino-3-(4-bromophenyl)propanoic acid hydrochloride; D-4-Bromophenylalanine HCl; (R)-4-Bromo-α-aminohydrocinnamic acid hydrochloride; H-D-4-Br-Phe-OH • HCl; 4-Bromo-D-α-aminophenylpropionic acid hydrochloride; p-Bromo-D-phenylalanine hydrochloride; (2R)-2-Azaniumyl-3-(4-bromophenyl)propanoate chloride
EINECS	Contact for details

Quality Control

Our 4-Bromo-D-Phenylalanine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for research and cGMP applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing specifications for identity, purity (by HPLC), chiral purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-Isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.