Description

L-Phenylalanine, 2-Fluoro-, Hydrochloride is a fluorinated derivative of the essential amino acid L-phenylalanine, presented as its hydrochloride salt for enhanced stability and handling. This modified amino acid is a critical building block in medicinal chemistry and pharmaceutical research, enabling the development of novel bioactive compounds. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of peptides, enzyme inhibitors, and potential therapeutic agents, where the introduction of a fluorine atom can significantly alter metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate fluorinated phenylalanine residues, modifying peptide stability, lipophilicity, and biological activity.
• Biochemical Research: Serves as a substrate analog in enzyme studies and metabolic pathway investigations to understand fluorine's effects on biological systems.
• Proteomics & Labeling: Potential use in the design of activity-based probes and mass spectrometry tags for protein analysis and imaging.
• Agrochemical Research: Employed in the discovery of novel fluorinated amino acid-based herbicides or plant growth regulators.

Basic Information

Product Name	L-Phenylalanine, 2-Fluoro-, Hydrochloride
CAS No.	122839-57-0
Molecular Formula	C9H11ClFNO2
Molecular Weight	219.64 g/mol
Synonyms	(2S)-2-Amino-3-(2-fluorophenyl)propanoic acid hydrochloride; 2-Fluoro-L-phenylalanine hydrochloride; F-Phe-OH·HCl; 2-F-Phe-OH·HCl; L-2-Fluorophenylalanine hydrochloride; (S)-2-Amino-3-(2-fluorophenyl)propionic acid hydrochloride; 2-Fluorophenylalanine HCl; 2-Fluoro-DL-phenylalanine hydrochloride (related)
EINECS	Contact for details

Quality Control

Our L-Phenylalanine, 2-Fluoro-, Hydrochloride is manufactured under controlled conditions to ensure high chemical purity and chiral integrity, suitable for demanding research applications. Each batch is subjected to rigorous analytical testing, including chiral HPLC to confirm enantiomeric purity and NMR for structural verification. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.