Description

3-Trifluoromethyl-L-Phenylalanine is a non-natural, fluorinated amino acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the unique properties imparted by the trifluoromethyl group, which can significantly enhance the metabolic stability, lipophilicity, and bioavailability of target molecules. This high-purity chiral compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially protease inhibitors and other bioactive peptides.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate fluorinated motifs that alter peptide conformation and interaction with biological targets.
• Agrochemical Research: Serves as a building block for designing novel herbicides, pesticides, and plant growth regulators with improved environmental persistence and efficacy.
• Chemical Biology & Proteomics: Employed as a molecular probe or labeled amino acid to study protein structure, function, and interactions through 19F NMR spectroscopy.
• Material Science: Potential monomer or modifier for creating specialty polymers and advanced materials with specific surface properties or stability.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting research in medicinal chemistry, fluorochemistry, and asymmetric synthesis.

Basic Information

Product Name	3-Trifluoromethyl-L-Phenylalanine
CAS No.	122839-48-9
Molecular Formula	C10H10F3NO2
Molecular Weight	233.19 g/mol
Synonyms	(S)-2-Amino-3-[3-(trifluoromethyl)phenyl]propanoic acid; L-3-(Trifluoromethyl)phenylalanine; (S)-3-(Trifluoromethyl)phenylalanine; 3-CF3-L-Phe; F3C-Phe-OH; α-Amino-3-(trifluoromethyl)benzenepropanoic acid; (S)-α-Amino-3-(trifluoromethyl)hydrocinnamic acid
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethyl-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.