Description

Trt-Lys(Fmoc)-Oh CAS NO 122832-81-9 is a protected amino acid derivative, specifically an Nα-Fmoc and Nε-trityl protected L-lysine, serving as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing orthogonal protection for the lysine side chain, enabling the controlled, sequential construction of complex peptides and bioconjugates. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research focused on creating novel therapeutic peptides, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the controlled incorporation of lysine residues using Fmoc-chemistry protocols.
• Pharmaceutical R&D: Synthesis of peptide-based drug candidates, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation: Preparation of peptide tags, linkers, and carriers for antibody-drug conjugates (ADCs) and other biopharmaceuticals.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Research: Synthesis of substrates, inhibitors, and standards for enzyme studies and assay development.
• Material Science: Building block for peptide-based polymers, hydrogels, and surface coatings with specific functionalities.

Basic Information

Product Name	Trt-Lys(Fmoc)-Oh
CAS No.	122832-81-9
Molecular Formula	C39H36N2O4
Molecular Weight	596.72 g/mol
Synonyms	Fmoc-Lys(Trt)-OH; Nα-Fmoc-Nε-trityl-L-lysine; Fmoc-Lys(Trt)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(tritylamino)hexanoic acid; Nα-(9-Fluorenylmethyloxycarbonyl)-Nε-trityl-L-lysine; Fmoc-Lys(Trt)-OH; Fmoc-Lys(Trt)-OH (peptide synthesis grade); Fmoc-Lys(Trt)-OH (SPPS reagent)
EINECS	Contact for details

Quality Control

Our Trt-Lys(Fmoc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, and is supplied with a comprehensive Certificate of Analysis (COA). We adhere to cGMP principles for active pharmaceutical ingredient (API) intermediates, and our quality standards meet the requirements for research and development use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions, moisture, or light may lead to decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	-10.0° to -12.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.