Description

4,6-Difluoro-2-Methylsulfanyl-Pyrimidine is a high-purity fluorinated pyrimidine derivative, a key building block in advanced organic synthesis. Its value lies in its unique molecular scaffold, which enables the introduction of both fluorine and sulfur functionalities into target molecules, a critical step in developing compounds with enhanced biological activity and physicochemical properties. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for antiviral, anticancer, and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the development of modern pesticides, herbicides, and fungicides, where the fluorine atoms improve metabolic stability and bioavailability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and electronic materials.
• Chemical Biology & Proteomics: Employed as a building block for synthesizing molecular probes, enzyme inhibitors, and labeled compounds for biochemical studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	4,6-Difluoro-2-Methylsulfanyl-Pyrimidine
CAS No.	122815-08-1
Molecular Formula	C5H4F2N2S
Molecular Weight	162.16 g/mol
Synonyms	2-(Methylthio)-4,6-difluoropyrimidine; 4,6-Difluoro-2-(methylthio)pyrimidine; 2-Methylsulfanyl-4,6-difluoropyrimidine; 4,6-Difluoro-2-methylmercaptopyrimidine; 4,6-Difluoro-2-(methylsulfanyl)pyrimidine; 4,6-Difluoro-2-(methylthio)-pyrimidine; 122815-08-1; Pyrimidine, 4,6-difluoro-2-(methylthio)-
EINECS	Contact for details

Quality Control

Every batch of 4,6-Difluoro-2-Methylsulfanyl-Pyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for sensitive synthesis applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, GC, NMR, and other relevant techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.