Description

4'-(Trifluoromethyl)[1,1'-Biphenyl]-2-Ol is a high-purity, functionalized biphenyl derivative featuring a phenolic hydroxyl group and a trifluoromethyl substituent. This compound is a versatile and valuable advanced pharmaceutical intermediate and key building block for organic synthesis, prized for its ability to impart unique physicochemical properties to target molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorine and biphenyl motifs into novel compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a key building block for developing new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic display materials, where the biphenyl core contributes to molecular alignment and stability.
• Organic Ligand for Catalysis: Functions as a precursor for creating specialized ligands in transition metal catalysis, enabling more efficient and selective chemical transformations.
• Polymer & Resin Modifier: Incorporated into specialty polymers to modify thermal stability, solubility, and optical properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in cross-coupling reactions and fluorine chemistry within research laboratories.

Basic Information

Product Name	4'-(Trifluoromethyl)[1,1'-Biphenyl]-2-Ol
CAS No.	122801-61-0
Molecular Formula	C₁₃H₉F₃O
Molecular Weight	238.21 g/mol
Synonyms	2-Hydroxy-4'-(trifluoromethyl)biphenyl; 2-Biphenylol, 4'-(trifluoromethyl)-; 4'-(Trifluoromethyl)-2-biphenylol; [1,1'-Biphenyl]-2-ol, 4'-(trifluoromethyl)-; 2-Hydroxy-4'-trifluoromethylbiphenyl; 4'-Trifluoromethylbiphenyl-2-ol; 2-(4-Trifluoromethylphenyl)phenol
EINECS	Contact for details

Quality Control

Our 4'-(Trifluoromethyl)[1,1'-Biphenyl]-2-Ol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and high-purity research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.