Description

3-(2-Naphthyl)-L-Alanine Hydrochloride is a high-purity, non-natural amino acid derivative essential for advanced peptide synthesis and pharmaceutical research. This compound serves as a critical building block for introducing the hydrophobic 2-naphthyl moiety into peptide chains, modulating their biological activity, stability, and binding affinity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of peptide-based drugs and candidates.
• Biochemical Research: Used to incorporate a bulky, aromatic side chain into model peptides for studying protein folding, receptor-ligand interactions, and enzyme specificity.
• Proteomics & Diagnostics: Employed in the design and synthesis of specialized peptide substrates, inhibitors, or fluorescent probes for diagnostic assays.
• Material Science: Potential building block for creating novel peptidomimetic polymers or surface modifiers with specific aromatic characteristics.

Basic Information

Item	Details
Product Name	3-(2-Naphthyl)-L-Alanine Hydrochloride
CAS No.	122745-12-4
Molecular Formula	C₁₃H₁₃NO₂·HCl
Molecular Weight	251.71 g/mol (Free base: 215.25)
Synonyms	L-3-(2-Naphthyl)alanine hydrochloride; (S)-2-Amino-3-(naphthalen-2-yl)propanoic acid hydrochloride; 2-Naphthyl-L-alanine HCl; 3-(2-Naphthyl)alanine hydrochloride, L-; H-2-Nal-OH·HCl; BOC-2-Nal-OH (precursor form); Fmoc-2-Nal-OH (precursor form); 2-Nal
EINECS	Contact for details

Quality Control

Our 3-(2-Naphthyl)-L-Alanine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing chiral purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.