Description

(R)-2-Amino-3-(2-Naphthalenyl)Propanoic Acid Hydrochloride is a high-purity chiral amino acid derivative, specifically the hydrochloride salt of the (R)-enantiomer of 2-amino-3-(naphthalen-2-yl)propanoic acid. This compound is a critical building block in pharmaceutical research and development, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and chiral ligands. It is essential for medicinal chemists and process development scientists working in the pharmaceutical, biotechnology, and fine chemical sectors who require enantiomerically pure intermediates for drug discovery programs targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a naphthylalanine derivative with specific stereochemistry, modifying peptide properties for research.
• Chiral Catalyst & Ligand Preparation: Serves as a precursor for synthesizing chiral auxiliaries, catalysts, and ligands used in asymmetric synthesis to induce enantioselectivity.
• Biochemical Research: Employed as a standard or probe in enzymatic studies and receptor binding assays to investigate stereospecific biological interactions.
• Academic & Process Chemistry: A valuable reagent for methodological development in organic synthesis and for scaling up enantioselective routes in process chemistry.

Basic Information

Product Name	(R)-2-Amino-3-(2-Naphthalenyl)Propanoic Acid Hydrochloride
CAS No.	122745-11-3
Molecular Formula	C₁₃H₁₃NO₂·HCl
Molecular Weight	251.71 g/mol (Free base: 215.25 g/mol)
Synonyms	(R)-2-Naphthylalanine hydrochloride; D-2-Naphthylalanine HCl; (R)-2-Amino-3-(naphthalen-2-yl)propanoic acid hydrochloride; (R)-3-(2-Naphthyl)alanine hydrochloride; (2R)-2-Amino-3-(naphthalen-2-yl)propanoic acid hydrochloride; (R)-β-(2-Naphthyl)-alanine HCl; (R)-2-Nal-OH·HCl; UNII-9J8F8Y6V6B
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-3-(2-Naphthalenyl)Propanoic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and chiral excess is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.