Description

3-(1-Naphthyl)-L-Alanine Hydrochloride is a non-natural, chiral amino acid derivative where the aromatic 1-naphthyl group is attached to the alanine backbone. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering enhanced structural rigidity and hydrophobic character. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery, particularly for developing enzyme inhibitors, receptor ligands, and novel therapeutic peptides.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a bulky, hydrophobic naphthyl side chain, influencing peptide folding and target binding.
• Enzyme Inhibitor Design: Serves as a core structure in designing potent and selective inhibitors for proteases and other enzymes.
• Chemical Biology Research: Employed in studying protein-protein interactions and developing fluorescent or affinity probes due to its aromatic properties.
• Asymmetric Synthesis: Acts as a chiral auxiliary or precursor in asymmetric catalytic reactions to induce stereoselectivity.
• Material Science: Potential use in creating functionalized polymers and advanced materials with specific chiral and aromatic properties.

Basic Information

Product Name	3-(1-Naphthyl)-L-Alanine Hydrochloride
CAS No.	122745-10-2
Molecular Formula	C₁₃H₁₄ClNO₂
Molecular Weight	251.71 g/mol
Synonyms	(S)-2-Amino-3-(naphthalen-1-yl)propanoic acid hydrochloride; L-1-Naphthylalanine hydrochloride; 1-Nal-OH.HCl; (S)-3-(1-Naphthyl)alanine HCl; 3-(1-Naphthalenyl)-L-alanine hydrochloride; 3-(α-Naphthyl)-L-alanine hydrochloride; Naphthalene-1-L-alanine hydrochloride; 122745-10-2
EINECS	Contact for details

Quality Control

Our 3-(1-Naphthyl)-L-Alanine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, specific rotation, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.