Description

Bovine Parathyroid Hormone (1-34)Nh2, Nle(8), Lys(n-ε-4-Azido-2-Nitrophenyl)(13), Nle(18), Tyr(34)- CAS NO 122633-61-8 is a bioactive, chemically modified fragment of bovine parathyroid hormone (PTH) designed for advanced research applications. This synthetic analog is engineered with specific amino acid substitutions and a photoactivatable cross-linking moiety, making it a critical tool for studying PTH receptor structure, function, and signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in endocrinology, bone metabolism research, and novel therapeutic development.

Application

• Biochemical Research: Fundamental studies on parathyroid hormone (PTH) action, receptor-ligand interactions, and calcium homeostasis mechanisms.
• Photaffinity Labeling: The incorporated 4-Azido-2-nitrophenyl (ANP) group enables covalent cross-linking to PTH1 receptors upon UV irradiation, allowing for receptor isolation, mapping of binding sites, and structural biology studies.
• Signal Transduction Analysis: Investigation of downstream signaling cascades (e.g., cAMP, PKC pathways) activated by PTH in target cells such as osteoblasts and renal tubular cells.
• Drug Discovery & Development: Serving as a key reference compound and probe in high-throughput screening assays and the development of PTH-based therapeutics for osteoporosis and other metabolic bone disorders.
• Receptor Characterization: Detailed pharmacological profiling of PTH receptor subtypes (PTH1R) to understand selectivity, affinity, and activation kinetics.
• Academic & Institutional Research: Supporting cutting-edge research in endocrinology, molecular biology, and skeletal physiology within university and government laboratories.

Basic Information

Product Name	Bovine Parathyroid Hormone (1-34)Nh2, Nle(8), Lys(n-ε-4-Azido-2-Nitrophenyl)(13), Nle(18), Tyr(34)- CAS NO 122633-61-8
CAS No.	122633-61-8
Molecular Formula	C181H282N56O51
Molecular Weight	~4109.6 g/mol
Synonyms	PTH (1-34), bovine, modified; [Nle8,18, Tyr34]-bPTH-(1-34)-amide; Bovine Parathyroid Hormone Fragment 1-34 amide, ANP-labeled; Photoactivatable PTH (1-34) analog; bPTH(1-34)NH2 [Nle8, Lys(ANP)13, Nle18, Tyr34]; Parathyroid Hormone (bovine) (1-34) amide, ANP derivative; PTH1-34 (bovine) cross-linking analog
EINECS	Contact for details

Quality Control

Our Bovine Parathyroid Hormone (1-34) analog is manufactured under strict quality systems to ensure high purity, batch-to-batch consistency, and biological activity. Each lot is subjected to a comprehensive suite of analytical tests, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by in vitro cAMP assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.