Description

H-Leu-Leu-Tyr-Glu-Met-Leu-Ala-Gly-Gln-Ala-Pro-Phe-Glu-Gly-Glu-Asp-Glu-Asp-Glu-Leu-Phe-Gln-Ser-Ile-Met-Glu-His-Asn-Val-Nh2 is a high-purity synthetic peptide sequence, also known as a fragment of the human parathyroid hormone-related protein (PTHrP). This compound is critical for advanced biochemical research and pharmaceutical development due to its specific biological activity. It is primarily utilized by research institutions and biopharmaceutical companies engaged in metabolic bone disease studies, cancer research, and peptide-based therapeutic discovery.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of calcium regulation and bone metabolism.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutics for hypercalcemia of malignancy and osteoporosis.
• Cell Signaling Studies: Employed to investigate PTH/PTHrP receptor (PTH1R) activation and downstream signaling pathways in vitro.
• Antibody Production: Acts as an immunogen for generating specific antibodies used in diagnostic assays and immunohistochemistry.
• Peptide Library Screening: A component in high-throughput screening libraries for drug discovery targeting G-protein-coupled receptors (GPCRs).
• Academic Research: Fundamental tool in university and institutional labs for endocrinology and molecular biology research.

Basic Information

Product Name	H-Leu-Leu-Tyr-Glu-Met-Leu-Ala-Gly-Gln-Ala-Pro-Phe-Glu-Gly-Glu-Asp-Glu-Asp-Glu-Leu-Phe-Gln-Ser-Ile-Met-Glu-His-Asn-Val-Nh2
CAS No.	122613-29-0
Molecular Formula	C148H229N41O53S2
Molecular Weight	~3325.8 g/mol
Synonyms	PTHrP (1-34) amide, human; Parathyroid Hormone-Related Protein (1-34) amide; hPTHrP(1-34)NH2; Ala1,Leu15-hPTHrP(1-34)NH2; PTHRP (1-34) (HUMAN); PTHrP 1-34 amide, human; PTHLH (1-34) (human) amide; Synthetic human PTHrP(1-34) amide fragment
EINECS	Contact for details

Quality Control

Our H-Leu-Leu-Tyr-Glu-Met-Leu-Ala-Gly-Gln-Ala-Pro-Phe-Glu-Gly-Glu-Asp-Glu-Asp-Glu-Leu-Phe-Gln-Ser-Ile-Met-Glu-His-Asn-Val-Nh2 is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring compliance with research-grade and cGMP guidelines for non-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.