Description

[(2S,5R)-5-(5-Methyl-2,4-Dioxo-Pyrimidin-1-Yl)-2,5-Dihydrofuran-2-Yl]Methyl Benzoate is a high-purity, advanced pharmaceutical intermediate with a complex chiral structure. This compound is critical for the synthesis of novel nucleoside analogues, offering researchers and manufacturers a reliable building block for developing targeted therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical producers engaged in antiviral and anticancer drug discovery programs.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel antiviral and anticancer nucleoside analogues.
• Antiviral Drug Research: Building block for the development of next-generation therapeutics targeting viral polymerases.
• Oncology Drug Discovery: Used in the research and development of chemotherapeutic agents that interfere with DNA/RNA synthesis.
• Biochemical Research: Serves as a reference standard and probe in enzymatic and metabolic pathway studies.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).
• Custom Synthesis: Starting material for the contract manufacturing of specialized, high-value fine chemicals.

Basic Information

Product Name	[(2S,5R)-5-(5-Methyl-2,4-Dioxo-Pyrimidin-1-Yl)-2,5-Dihydrofuran-2-Yl]Methyl Benzoate
CAS No.	122567-97-9
Molecular Formula	C₁₇H₁₆N₂O₅
Molecular Weight	328.32 g/mol
Synonyms	Benzoic acid, [(2S,5R)-5-(5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-2,5-dihydro-2-furanyl]methyl ester; (2S,5R)-5-(5-Methyl-2,4-dioxopyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethyl benzoate; 1-[(2S,5R)-5-[(Benzoyloxy)methyl]-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 5-Methyl-1-[(2S,5R)-5-[(benzoyloxy)methyl]-2,5-dihydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; Chiral Dihydrofuran Nucleoside Intermediate
EINECS	Contact for details

Quality Control

Our [(2S,5R)-5-(5-Methyl-2,4-Dioxo-Pyrimidin-1-Yl)-2,5-Dihydrofuran-2-Yl]Methyl Benzoate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.