Description

Boc-Lys(2-Picolinoyl)-OH is a protected amino acid derivative, specifically a lysine residue modified with a Boc (tert-butoxycarbonyl) protecting group on the α-amine and a 2-picolinoyl group on the side-chain ε-amine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of modified lysine to introduce specific functionalities or enhance peptide stability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptide-based diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled introduction of a modified lysine residue into peptide chains.
• Therapeutic Peptide Development: Used in the research and production of peptide drugs where side-chain modification is required for activity, stability, or pharmacokinetics.
• Bioconjugation and Labeling: The reactive carboxyl group allows for further conjugation to other molecules, carriers, or fluorescent tags.
• Chemical Biology Research: Serves as a tool compound for studying protein-protein interactions and enzyme mechanisms by incorporating non-natural amino acids.
• Peptide Library Construction: Essential for creating diverse peptide libraries for screening in drug discovery and biomarker identification.

Basic Information

Product Name	Boc-Lys(2-Picolinoyl)-OH
CAS No.	122532-80-3
Molecular Formula	C₁₈H₂₅N₃O₅
Molecular Weight	363.41 g/mol
Synonyms	Nα-(tert-Butoxycarbonyl)-Nε-(2-pyridinecarbonyl)-L-lysine; Boc-Lys(Pic)-OH; (2S)-6-[(Pyridine-2-carbonyl)amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid; N-Boc-N'-picolinoyl-L-lysine; tert-Butyl N-[(2S)-6-[(pyridine-2-carbonyl)amino]-1-(hydroxyamino)-1-oxohexan-2-yl]carbamate (open acid form); Boc-L-lysine(N-2-picolinoyl)-OH
EINECS	Contact for details

Quality Control

Our Boc-Lys(2-Picolinoyl)-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, chiral analysis to confirm enantiomeric purity, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure the material meets the high standards required for pharmaceutical research and peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.