Description

(D-Pen2,p-Chloro-Phe4,D-Pen5)-Enkephalin CAS NO 122507-47-5 is a synthetic, highly selective delta opioid receptor (DOP) antagonist peptide. This compound is a critical research tool for neuropharmacology, enabling the specific blockade of delta opioid receptors to study their function in pain modulation, addiction, and mood disorders. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on central nervous system (CNS) drug discovery and neurobiological research.

Application

• Neuroscience Research: Fundamental studies on the role of delta opioid receptors in the brain and spinal cord.
• Pain Mechanism Investigation: Used to dissect the contribution of DOP receptors to analgesic pathways and chronic pain states.
• Psychopharmacology Studies: Research into the involvement of delta opioid systems in depression, anxiety, and reward processing.
• Drug Discovery & Development: A key reference standard and pharmacological tool for screening and characterizing new analgesic or neuropsychiatric drug candidates.
• Receptor Binding Assays: Employed in competitive binding experiments to determine receptor affinity and selectivity.
• In vivo Behavioral Models: Administration in animal models to study behavioral effects related to opioid receptor blockade.

Basic Information

Product Name	(D-Pen2,p-Chloro-Phe4,D-Pen5)-Enkephalin
CAS No.	122507-47-5
Molecular Formula	C34H38ClN5O7S2
Molecular Weight	728.27 g/mol
Synonyms	D-Penicillamine (2,5)-Enkephalin, p-Cl-Phe(4) analog; [D-Pen2, p-Cl-Phe4, D-Pen5]Enkephalin; DPLPE; Delta Opioid Receptor Antagonist; (2-D-Penicillamine, 5-D-Penicillamine)-Enkephalin; Tyr-D-Pen-Gly-p-Cl-Phe-D-Pen-OH; p-Chloro-Phenylalanine4, D-Penicillamine2,5-Enkephalin
EINECS	Contact for details

Quality Control

Our (D-Pen2,p-Chloro-Phe4,D-Pen5)-Enkephalin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.