Description

(D-Arg1,D-Trp5·7·9,Leu11)-Substance P H-D-Arg-Pro-Lys-Pro-D-Trp-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2 is a potent, selective neurokinin-1 (NK1) receptor antagonist derived from the Substance P peptide sequence. This compound is of significant value for research into neuroinflammatory pathways, pain signaling, and the role of tachykinins in various physiological processes. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, oncology, and immunology.

Application

• Neuroscience Research: Used as a selective antagonist to study the role of Substance P and NK1 receptors in pain transmission, migraine, and neurogenic inflammation.
• Pharmacological Studies: Serves as a critical reference standard and tool compound for in vitro and in vivo assays to evaluate new analgesic or anti-inflammatory drug candidates.
• Oncology Research: Investigated for its potential effects on cancer cell proliferation and metastasis, where Substance P signaling pathways are implicated.
• Immunology Research: Employed to explore neuro-immune interactions, particularly in conditions involving neurogenic inflammation and immune cell modulation.
• Biochemical Assay Development: Utilized as a high-purity ligand in receptor binding studies and functional assays to characterize NK1 receptor activity.

Basic Information

Product Name	(D-Arg1,D-Trp5·7·9,Leu11)-Substance P H-D-Arg-Pro-Lys-Pro-D-Trp-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2
CAS No.	122481-75-8
Molecular Formula	C86H122N24O14
Molecular Weight	1683.06 g/mol
Synonyms	Substance P (D-Arg1, D-Trp5,7,9, Leu11)-; [D-Arg1, D-Trp5,7,9, Leu11]-Substance P; Neurokinin 1 Receptor Antagonist (D-Arg1, D-Trp5,7,9, Leu11)-Substance P; H-D-Arg-Pro-Lys-Pro-D-Trp-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2; NK1 Receptor Antagonist Peptide; SP Analogue (D-Arg1, D-Trp5,7,9, Leu11)-; Tachykinin Receptor Antagonist
EINECS	Contact for details

Quality Control

Our (D-Arg1,D-Trp5·7·9,Leu11)-Substance P is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.