Description

Big Endothelin is a synthetic peptide analog of the potent vasoconstrictor endothelin-1, specifically designed for research and development applications. This compound is crucial for studying cardiovascular physiology, vascular tone regulation, and receptor-ligand interactions in biochemical pathways. It serves as an essential tool for pharmaceutical researchers, academic institutions, and diagnostic developers focused on hypertension, pulmonary arterial hypertension, and related vascular diseases.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of endothelin receptor (ETA and ETB) signaling and function.
• Pharmacology Screening: Employed in high-throughput assays to screen and evaluate potential endothelin receptor antagonists for drug discovery.
• Vascular Biology Studies: Applied in ex vivo and in vitro models to investigate mechanisms of vasoconstriction, vascular smooth muscle cell proliferation, and endothelial dysfunction.
• Diagnostic Development: Utilized in the calibration and development of immunoassays (e.g., ELISA) and other diagnostic kits targeting the endothelin system.
• Academic & Institutional Use: Serves as a critical reagent for university laboratories and research institutes conducting cardiovascular and physiological research.
• Biochemical Pathway Analysis: Acts as a specific agonist to probe and map intracellular signaling cascades initiated by endothelin receptor activation.

Basic Information

Product Name	Big Endothelin
CAS No.	122462-75-3
Molecular Formula	C109H159N29O32S5
Molecular Weight	2461.9 g/mol
Synonyms	Endothelin (16-38), human; Big ET; Big Endothelin-1; Big ET-1; Proendothelin-1 (16-38); [Cys1,3,11,15, Ala7]-Endothelin-1 (16-38); ET (16-38); Human Big Endothelin Fragment
EINECS	Contact for details

Quality Control

Our Big Endothelin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to relevant guidelines for peptide synthesis and can provide material suitable for use under GMP conditions for non-clinical research, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.