Description

9-Trityladenine 1-n-Oxide is a specialized, protected nucleobase derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound is valued for its role as a key synthetic intermediate, particularly in the preparation of modified nucleosides and nucleotides where the trityl group provides selective protection. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and agrochemical industries for developing novel active ingredients and exploring new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the preparation of modified DNA/RNA sequences for research, diagnostics, and therapeutic applications.
• Medicinal Chemistry Research: Acts as a protected adenine derivative for structure-activity relationship (SAR) studies and prodrug development.
• Bioconjugation Chemistry: Provides a functional handle for attaching biomolecules or probes due to its reactive N-oxide moiety.
• Agrochemical Research: Investigated as an intermediate for developing new plant growth regulators or pesticides with novel modes of action.
• Chemical Biology Probes: Utilized in the creation of labeled nucleotides or affinity probes for studying enzyme mechanisms and cellular processes.

Basic Information

Product Name	9-Trityladenine 1-n-Oxide
CAS No.	122365-36-0
Molecular Formula	C24H19N5O
Molecular Weight	393.44 g/mol
Synonyms	9-(Triphenylmethyl)adenine 1-Oxide; 9-Trityl-1-hydroxyadenine; 1-Hydroxy-9-trityladenine; N1-Hydroxy-9-trityladenine; 9-Trityl-1H-purin-6-amine 1-oxide; 9-(Triphenylmethyl)-1H-purin-6-amine 1-oxide; Adenine, 9-(triphenylmethyl)-, 1-oxide; Tritylated Adenine N-Oxide
EINECS	Contact for details

Quality Control

Our 9-Trityladenine 1-n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.