Description

Eglin C (41-49) is a synthetic peptide fragment derived from the potent elastase inhibitor Eglin c, corresponding to amino acid residues 41 through 49. This well-defined peptide sequence is a valuable tool for biochemical research and pharmaceutical development, particularly in the study of protease inhibition mechanisms. It is primarily utilized by researchers in pharmaceutical R&D, academic biochemistry labs, and biotechnology companies focused on inflammation and respiratory diseases.

Application

• Biochemical Research: Used as a reference standard and active probe in studies of serine protease inhibition, specifically targeting human leukocyte elastase (HLE).
• Drug Discovery: Serves as a lead compound or structural template for the development of novel anti-inflammatory and anti-protease therapeutic agents.
• Enzyme Kinetics: Employed in in vitro assays to determine inhibitory constants (Ki) and elucidate the structure-activity relationship (SAR) of elastase inhibitors.
• Pharmaceutical Intermediate: Acts as a key synthetic building block for constructing larger peptide conjugates or modified analogs with enhanced stability or activity.
• Quality Control: Functions as a system suitability standard in analytical methods (e.g., HPLC, LC-MS) for related peptide pharmaceuticals.

Basic Information

Product Name	Eglin C (41-49)
CAS No.	122299-11-0
Molecular Formula	C44H68N14O13
Molecular Weight	977.1 g/mol
Synonyms	Eglin c (41-49); Eglin-C 41-49; H-Arg-Cys-Met-Arg-Ile-Pro-Gly-Tyr-Phe-OH; Eglin C Fragment 41-49; Acetylcholine esterase inhibitor peptide (41-49); Elastase inhibitor peptide fragment; Leupeptin analog; Protease inhibitor peptide sequence 41-49
EINECS	Contact for details

Quality Control

Our Eglin C (41-49) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry (MS) for identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Amino Acid Analysis	Within ± 10% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.