Description

Dansyl-Arginyl-Phenylalaninamide is a synthetic, dansyl-labeled tripeptide derivative designed for advanced biochemical research and development. This compound is particularly valuable as a highly sensitive fluorogenic substrate for studying protease activity and enzyme kinetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, proteomics, and diagnostic assay development. The dansyl fluorophore provides a robust signal for detection, making it an essential tool for high-throughput screening and mechanistic studies.

Application

• Protease/Enzyme Substrate: Acts as a specific fluorogenic substrate for studying the activity and inhibition of various proteases, including trypsin-like enzymes.
• Biochemical Research: Used in fundamental research to investigate peptide cleavage mechanisms, enzyme specificity, and kinetic parameters.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) assays to identify and characterize novel protease inhibitors as potential therapeutic agents.
• Diagnostic Development: Serves as a key component in the development of fluorescent diagnostic assays for detecting enzymatic activity in clinical samples.
• Proteomics & Biomarker Studies: Utilized in proteomic workflows to profile protease activity in complex biological samples, aiding in biomarker discovery.
• Quality Control Reagent: Applied in the quality control of enzyme preparations and related biopharmaceutical products.

Basic Information

Product Name	Dansyl-Arginyl-Phenylalaninamide
CAS No.	122061-69-2
Molecular Formula	C32H47N9O6S
Molecular Weight	685.85 g/mol
Synonyms	Dns-Arg-Phe-NH2; Dansyl-Arg-Phe-amide; 5-(Dimethylamino)naphthalene-1-sulfonyl-arginyl-phenylalaninamide; DAP; Dns-R-F-NH2; Nα-(5-Dimethylaminonaphthalene-1-sulfonyl)-L-arginyl-L-phenylalaninamide; Fluorogenic Peptide Substrate DAP
EINECS	Contact for details

Quality Control

Our Dansyl-Arginyl-Phenylalaninamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.