Description

Corticotropin Release-Inhibiting Factor CAS NO 122018-92-2 is a synthetic peptide analog of the endogenous hormone that regulates the hypothalamic-pituitary-adrenal (HPA) axis. This compound is of significant interest for its potential to modulate stress response pathways and related physiological functions. It is primarily utilized by research institutions and pharmaceutical developers focused on endocrinology, neurobiology, and the development of novel therapeutic agents for stress-related disorders.

Application

• Biomedical Research: Used as a critical tool in laboratory studies to investigate the mechanisms of corticotropin-releasing hormone (CRH) inhibition and HPA axis regulation.
• Pharmacological Development: Serves as a reference standard or lead compound in the discovery and screening of new drugs targeting stress, anxiety, depression, and related conditions.
• Endocrine Studies: Applied in in vitro and in vivo models to study the feedback inhibition of adrenocorticotropic hormone (ACTH) release.
• Neuroscience Research: Utilized to explore the role of CRH-inhibiting factors in central nervous system function and behavior.
• Diagnostic Assay Development: May be employed in the development and calibration of immunoassays or other analytical methods for related biomarkers.

Basic Information

Item	Details
Product Name	Corticotropin Release-Inhibiting Factor
CAS No.	122018-92-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Corticotropin Release-Inhibiting Factor (CRIF); CRH-Inhibiting Factor; Corticotropin-Inhibiting Factor; CRIF (1-12); Prepro-CRF (127-138); Human Corticotropin Release-Inhibiting Factor; hCRIF; CRH Antagonist Peptide Fragment
EINECS	Contact for details

Quality Control

Our Corticotropin Release-Inhibiting Factor is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. All materials undergo comprehensive analytical testing, including HPLC for purity and MS for identity confirmation. A detailed Certificate of Analysis (COA) documenting purity, peptide content, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.