Description

Prepro-Thyrotropin Releasing Hormone (160-169) is a specific peptide fragment derived from the prepro-thyrotropin releasing hormone precursor protein. This compound is a critical research-grade biochemical tool for studying the biosynthesis, processing, and biological activity of thyrotropin-releasing hormone (TRH) and related neuroendocrine pathways. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on neuroendocrinology, peptide chemistry, and drug discovery.

Application

• Biochemical Research: Used as a reference standard and substrate in studies investigating the enzymatic processing and maturation of thyrotropin-releasing hormone (TRH).
• Neuroendocrine Studies: Essential for exploring the regulation of the hypothalamic-pituitary-thyroid axis and related signaling mechanisms.
• Pharmaceutical Development: Serves as a key intermediate or analytical standard in the development of diagnostic assays or therapeutic agents targeting TRH pathways.
• Peptide Synthesis & Characterization: Acts as a building block or model compound for method development in peptide synthesis, purification, and analytical techniques like HPLC and mass spectrometry.
• Cell Biology & In Vitro Assays: Employed in cell-based assays to study receptor interactions, signal transduction, and the physiological effects of TRH precursor fragments.

Basic Information

Item	Details
Product Name	Prepro-Thyrotropin Releasing Hormone (160-169)
CAS No.	122018-91-1
Molecular Formula	C52H78N16O14
Molecular Weight	1151.3 g/mol
Synonyms	Prepro-TRH (160-169); TRH Precursor Peptide (160-169); pGlu-His-Pro-Gly-Lys-Arg-Asn-Gln-Gln-Pro-Gly; Pyroglutamyl-His-Pro-Gly-Lys-Arg-Asn-Gln-Gln-Pro-Gly; Prepro-thyrotropin-releasing hormone fragment 160-169; TRH-Gly; TRH precursor decapeptide; pGlu-His-Pro-Gly-Lys-Arg-Asn-Gln-Gln-Pro-Gly-OH
EINECS	Contact for details

Quality Control

Our Prepro-Thyrotropin Releasing Hormone (160-169) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reliable and reproducible results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Composition	±10% of theoretical
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.