Description

21R-Argatroban is a highly potent and selective direct thrombin inhibitor, a critical active pharmaceutical ingredient (API) in the development and manufacture of anticoagulant medications. Its primary value lies in its ability to provide precise and reversible anticoagulation, making it essential for therapeutic applications where heparin is contraindicated. This compound is primarily needed by pharmaceutical manufacturers and research institutions focused on cardiovascular therapies, particularly for treating heparin-induced thrombocytopenia (HIT) and preventing thrombosis during percutaneous coronary interventions.

Application

• Active Pharmaceutical Ingredient (API): Core component in the formulation of injectable anticoagulant drugs.
• Heparin-Induced Thrombocytopenia (HIT) Treatment: Key therapeutic agent for patients who develop this serious complication.
• Percutaneous Coronary Intervention (PCI): Used as an anticoagulant during angioplasty and stent placement procedures.
• Thrombin Inhibition Research: Vital reference standard and tool in biochemical and pharmacological studies of blood coagulation pathways.
• Formulation Development: Used in R&D for creating new dosage forms and drug delivery systems for anticoagulation therapy.
• Clinical Trial Material (CTM): Supplied as a high-purity compound for use in clinical research studies.

Basic Information

Product Name	21R-Argatroban
CAS No.	121785-71-5
Molecular Formula	C23H36N6O5S
Molecular Weight	508.64 g/mol
Synonyms	Argatroban; (2R,4R)-4-Methyl-1-[N2-((RS)-3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid; MD-805; Novastan; Slonnon; Argipidine; (2R,4R)-4-Methyl-1-[N2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinylsulfonyl)-L-arginyl]-2-piperidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 21R-Argatroban is manufactured under strict quality systems to meet the rigorous standards required for pharmaceutical intermediates and APIs. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral purity, residual solvent analysis, and identification tests. A Certificate of Analysis (COA) is provided with every shipment, detailing compliance with agreed specifications. We support development and commercial needs with material suitable for applications requiring high chemical and isomeric purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% (21R-Argatroban)
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.