Description

Sarafotoxin S6C is a highly selective and potent endothelin B (ETB) receptor agonist, a synthetic analog of the natural sarafotoxin peptides. This compound is a critical pharmacological tool for scientific research, enabling the specific study of ETB receptor-mediated signaling pathways and physiological effects. It is primarily utilized by researchers and pharmaceutical developers in cardiovascular research, neurobiology, and oncology to investigate vasoconstriction, cell proliferation, and disease mechanisms.

Application

• Pharmacological Research: A standard tool compound for selectively activating endothelin B (ETB) receptors in in vitro and in vivo studies.
• Cardiovascular Studies: Used to model ETB receptor-mediated vasoconstriction and vasodilation, investigating hypertension, pulmonary arterial hypertension, and heart failure.
• Neuroscience Research: Applied in studies of the central and peripheral nervous systems to examine the role of endothelin signaling in pain, glial cell activation, and neurodegenerative conditions.
• Cancer Biology: Employed to probe the function of ETB receptors in tumor angiogenesis, cancer cell proliferation, and metastasis.
• Signal Transduction Assays: Used in high-throughput screening (HTS) and functional assays to identify and characterize ETB receptor antagonists or modulators.
• Academic & Institutional R&D: Essential for university and research institute laboratories focused on peptide hormones, G-protein coupled receptors (GPCRs), and drug discovery.

Basic Information

Product Name	Sarafotoxin S6C
CAS No.	121695-87-2
Molecular Formula	C119H179N35O32S6
Molecular Weight	2740.3 g/mol
Synonyms	Sarafotoxin S6c; Sarafotoxin 6c; S6C; Endothelin B Receptor Agonist S6C; SRTX S6C; SRTX-S6C; SRTX6c; [Cys1,15, Ala3,11]Sarafotoxin-b; Cyclo(1-15)[Cys1-Cys15][Cys1,15,Ala3,11]sarafotoxin b
EINECS	Contact for details

Quality Control

Our Sarafotoxin S6C is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Our quality commitment supports reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.