Description

Hemoglobin S Providence is a specific variant of hemoglobin, the oxygen-carrying protein in red blood cells, characterized by a defined amino acid substitution. This compound is of significant value for biochemical research and diagnostic development, particularly in the study of hemoglobinopathies and sickle cell disease. It is essential for researchers and manufacturers in the fields of clinical diagnostics, hematology research, and biopharmaceutical development who require high-purity reference materials.

Application

• Biochemical Research Standard: Used as a critical reference standard in studies of hemoglobin structure, function, and genetic mutations.
• Diagnostic Kit Development: Serves as a key component or calibrator in the development of in-vitro diagnostic (IVD) assays for detecting hemoglobin variants.
• Hematology Studies: Employed in laboratory investigations into sickle cell disease mechanisms and related blood disorders.
• Pharmaceutical R&D: Utilized in drug discovery and development programs targeting sickle cell disease and other hemoglobin-related conditions.
• Quality Control Material: Acts as a control material in clinical laboratories to ensure the accuracy of hemoglobin electrophoresis and chromatography methods.
• Educational & Training Tool: Provides a defined sample for teaching and training purposes in medical and life science education.

Basic Information

Product Name	Hemoglobin S Providence
CAS No.	121650-82-6
Molecular Formula	C3032H4816N780O872S40Fe4 (Approximate, for human hemoglobin tetramer)
Molecular Weight	~64,500 Da (Approximate)
Synonyms	Hb S Providence; Hemoglobin S (Providence); Hemoglobin β-6 Glu->Lys (Providence); HBB: c.20A>C (p.Glu7Lys); Hemoglobin variant Providence; Abnormal Hemoglobin S Providence; Deoxyhemoglobin S Providence; Oxyhemoglobin S Providence
EINECS	Contact for details

Quality Control

Our Hemoglobin S Providence is produced and handled under stringent quality systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and biological relevance. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as purity (by HPLC), spectral properties, and functional characteristics. We adhere to ISO 13485 principles for quality management, supporting its use in research and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive) and should be handled under controlled conditions to prevent degradation.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Assay (Functional)	Contact for details
Absorbance Ratio (A540/A280)	Specified range
Solubility	Clear solution in specified buffer
Endotoxin	< 1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.