Description

5-Bromo-2-(tert-Butoxy)Pyrimidine is a high-purity, functionalized pyrimidine derivative serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of bromine and a tert-butoxy group, which act as versatile handles for further chemical modifications, enabling the construction of complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleoside & Nucleotide Chemistry: Used in the modification and synthesis of nucleoside analogs for medicinal chemistry applications.
• Chemical Biology: Employed as a probe or linker in the development of biochemical tools and diagnostic agents.

Basic Information

Product Name	5-Bromo-2-(tert-Butoxy)Pyrimidine
CAS No.	121487-13-6
Molecular Formula	C8H11BrN2O
Molecular Weight	231.09 g/mol
Synonyms	5-Bromo-2-(1,1-dimethylethoxy)pyrimidine; 2-tert-Butoxy-5-bromopyrimidine; 5-Bromo-2-(tert-butoxy)pyrimidine; 5-Bromo-2-(tert-butoxy)pyrimidine; 5-Bromo-2-(tert-butoxy)pyrimidine; 5-Bromo-2-(tert-butoxy)pyrimidine; 5-Bromo-2-(tert-butoxy)pyrimidine; 5-Bromo-2-(tert-butoxy)pyrimidine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(tert-Butoxy)Pyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, assay, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material for research, pilot, or commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.