Description

Boc-Dl-Histidine is a protected derivative of the amino acid histidine, featuring a tert-butoxycarbonyl (Boc) group on the α-amino nitrogen. This compound is a crucial building block in peptide synthesis, where it serves to protect the reactive amine functionality during coupling reactions, thereby preventing unwanted side products and improving yield. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who are developing peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental protected amino acid for the automated, stepwise construction of complex peptide chains.
• Solution-Phase Peptide Synthesis: Used in traditional coupling methodologies for producing custom peptides and small protein fragments.
• Pharmaceutical Intermediate: Serves as a key raw material in the research and development of novel peptide drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in studies of enzyme-substrate interactions, receptor binding, and the structure-activity relationships of histidine-containing peptides.
• Protecting Group Chemistry: The Boc group is a standard, acid-labile protecting group, making this compound a model substrate for studying deprotection kinetics and conditions.
• Combinatorial Library Synthesis: Used to create diverse arrays of histidine-modified compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	Boc-Dl-Histidine
CAS No.	121428-29-3
Molecular Formula	C11H19N3O4
Molecular Weight	257.29 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-DL-histidine; Boc-His-OH (racemic); (RS)-2-[(tert-Butoxycarbonyl)amino]-3-(1H-imidazol-4-yl)propanoic acid; DL-N-Boc-histidine; tert-Butoxycarbonyl-DL-histidine; BOC-DL-HIS-OH; N-Boc-DL-histidine; UNII-8V8T8Q179M
EINECS	Contact for details

Quality Control

Our Boc-Dl-Histidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and reliability for your critical research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of water, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	Racemic mixture (DL)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.