Description

Amylin (14-20) (Human) is a specific, bioactive fragment of the human amylin hormone, a peptide co-secreted with insulin from pancreatic β-cells. This synthetic peptide is crucial for research into metabolic regulation, insulin resistance, and type 2 diabetes pathophysiology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on endocrinology and metabolic disease studies. The compound, identified by CAS number 121341-77-3, serves as a vital tool for investigating amylin's role in glycemic control and its potential therapeutic applications.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel diabetes and obesity therapeutics.
• Biochemical Assay Development: Serves as a critical component in the development and validation of immunoassays (ELISA, RIA) to detect and quantify amylin or related peptides.
• Mechanism of Action Studies: Employed in in vitro and in vivo research to elucidate the specific biological functions and receptor interactions of the amylin (14-20) sequence.
• Academic & Clinical Research: A key reagent for university and hospital laboratories studying islet amyloid polypeptide (IAPP) aggregation, β-cell dysfunction, and metabolic syndrome.
• Peptide Chemistry & Conjugation: Acts as a building block for the synthesis of longer peptide analogs or for conjugation in drug delivery and diagnostic probe development.

Basic Information

Product Name	Amylin (14-20) (Human)
CAS No.	121341-77-3
Molecular Formula	C35H58N10O10S
Molecular Weight	810.97 g/mol
Synonyms	Human Amylin (14-20); IAPP (14-20); Islet Amyloid Polypeptide Fragment (14-20); H-Amylin(14-20); Amylin Fragment 14-20; H-Ile-Leu-Ser-Thr-Asn-Val-Gly-OH (I-L-S-T-N-V-G); (14-20)-Amylin; Diabetes-Associated Peptide Fragment (14-20)
EINECS	Contact for details

Quality Control

Our Amylin (14-20) (Human) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from advanced techniques including HPLC for purity, MS for identity confirmation, and amino acid analysis. We support research and development requiring materials produced to cGMP guidelines for non-clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.