Description

H-His-Leu-Pro-Pro-Pro-Val-Oh CAS NO 121305-29-1 is a synthetic hexapeptide with the sequence Histidine-Leucine-Proline-Proline-Proline-Valine. This compound is of significant interest in biochemical and pharmaceutical research due to its specific amino acid sequence, which can be designed to mimic bioactive regions of larger proteins or to study structure-activity relationships. It serves as a critical intermediate or reference standard for researchers and manufacturers in the fields of peptide therapeutics, diagnostic development, and advanced life science applications.

Application

• Pharmaceutical Research & Development: Used as a key intermediate in the synthesis of novel peptide-based drug candidates and for studying metabolic pathways.
• Biochemical Assay Standard: Acts as a high-purity reference standard for calibrating analytical instruments like HPLC and Mass Spectrometry in quality control labs.
• Peptide Library Synthesis: A building block for constructing combinatorial peptide libraries used in high-throughput screening for drug discovery.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental studies in proteomics, enzymology, and molecular biology.
• Diagnostic Reagent Development: Serves as a component or antigen in the development of immunoassays and diagnostic kits.

Basic Information

Product Name	H-His-Leu-Pro-Pro-Pro-Val-Oh
CAS No.	121305-29-1
Molecular Formula	C34H53N9O8
Molecular Weight	715.85 g/mol
Synonyms	H-His-Leu-Pro-Pro-Pro-Val-OH; Histidyl-Leucyl-Prolyl-Prolyl-Prolyl-Valine; Hexapeptide H-His-Leu-Pro-Pro-Pro-Val-OH; HHLPPP; L-Histidyl-L-leucyl-L-prolyl-L-prolyl-L-prolyl-L-valine; CAS 121305-29-1; Peptide Sequence 34-39 (Angiotensinogen); (Sequence) HLPPP
EINECS	Contact for details

Quality Control

Every batch of H-His-Leu-Pro-Pro-Pro-Val-Oh is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.