Description

Endothelin 1, Ala(3,11)- is a synthetic, site-directed analog of the potent vasoconstrictor peptide Endothelin-1. This modified peptide is a critical research tool for investigating the structure-activity relationships and receptor binding mechanisms of the endothelin system. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies focused on cardiovascular disease, pulmonary hypertension, and cancer research.

Application

• Biomedical Research: Used as a specific ligand in receptor binding assays and competition studies to elucidate the function of endothelin receptors (ETA and ETB).
• Pharmacology Studies: Serves as a reference standard and tool compound for screening and developing novel endothelin receptor antagonists.
• Signal Transduction Research: Applied in studies to understand the intracellular signaling pathways activated by endothelin peptides.
• Cardiovascular Disease Models: Employed in *in vitro* and *ex vivo* models to study vasoconstriction, vascular smooth muscle cell proliferation, and the pathophysiology of hypertension.
• Academic & Institutional Use: A key reagent for graduate and post-doctoral research in biochemistry, molecular biology, and physiology departments.

Basic Information

Product Name	Endothelin 1, Ala(3,11)-
CAS No.	121185-73-7
Molecular Formula	C109H159N25O32S5
Molecular Weight	2488.0 g/mol (approximately)
Synonyms	[Ala3,11]-Endothelin-1; Endothelin-1, [Ala3,11]-; Ala(3,11)-Endothelin 1; ET-1 [Ala3,11]; H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bridge: Cys1-Cys15 and Cys3-Cys11); Endothelin-1 analog
EINECS	Contact for details

Quality Control

Our Endothelin 1, Ala(3,11)- is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization. Certificates of Analysis (COA) detailing purity, identity, and peptide content are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider aliquoting to minimize freeze-thaw cycles and maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.