Description

Desirudin CAS NO 120993-53-5 is a highly specific, direct thrombin inhibitor used as an active pharmaceutical ingredient (API). This recombinant hirudin analogue offers significant advantages in anticoagulant therapy due to its predictable pharmacokinetics and minimal interaction with other plasma proteins. It is primarily required by pharmaceutical manufacturers and research institutions developing next-generation antithrombotic and cardiovascular medications.

Application

• Pharmaceutical API: Core active ingredient in injectable anticoagulant drugs for the prevention of venous thromboembolism (VTE).
• Clinical Research: Used in studies investigating novel anticoagulation protocols, especially in patients with heparin-induced thrombocytopenia (HIT).
• Biochemical Research: A critical tool for studying thrombin's role in coagulation cascades, inflammation, and cellular proliferation.
• Diagnostic Development: Employed in the calibration and validation of diagnostic assays measuring thrombin activity and antithrombin therapies.
• Formulation Development: Used in R&D for creating stable parenteral formulations, including lyophilized (freeze-dried) powders.

Basic Information

Product Name	Desirudin
CAS No.	120993-53-5
Molecular Formula	C287H440N80O110S6
Molecular Weight	6963.5 g/mol
Synonyms	Desirudin Recombinant; Recombinant Desirudin; Revasc; Iprivask; CGP 39393; EC 3.4.21.-; Desulfatohirudin; Hirudin variant-1; (Leu1, Thr2)-63-desulfatohirudin
EINECS	Contact for details

Quality Control

Our Desirudin is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety, aligning with ICH Q7 guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (Related Substances, HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 10.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Bacterial Endotoxins (LAL)	< 10 EU/mg
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.