Description

H-Pro-Leu-Gly-Nhoh Hcl is a synthetic peptide derivative, specifically a hydroxamic acid-containing tripeptide, with the CAS registry number 120928-08-7. This compound is a valuable biochemical tool and building block in advanced research and development, particularly valued for its role as a potent inhibitor of metalloproteinases. It is essential for pharmaceutical researchers, biochemists, and contract research organizations (CROs) focused on developing novel therapeutics for conditions involving extracellular matrix remodeling, such as cancer metastasis, inflammatory diseases, and tissue repair.

Application

• Biochemical Research: Serves as a critical reference standard and active inhibitor in enzymatic studies of matrix metalloproteinases (MMPs) and other zinc-dependent proteases.
• Pharmaceutical Development: Used as a key intermediate or pharmacophore in the discovery and synthesis of new drug candidates targeting arthritis, cardiovascular diseases, and tumor progression.
• Protease Inhibition Studies: Employed in vitro and in cell-based assays to elucidate the mechanism of action and potency of hydroxamate-based inhibitors.
• Academic Research: A fundamental reagent for universities and research institutes studying protein degradation, signal transduction pathways, and enzyme kinetics.
• Diagnostic Kit Development: Can be utilized in the formulation of diagnostic assays and kits designed to measure specific protease activity in biological samples.

Basic Information

Product Name	H-Pro-Leu-Gly-Nhoh Hcl
CAS No.	120928-08-7
Molecular Formula	C14H25N5O4 • HCl
Molecular Weight	363.84 g/mol (free base: 327.38)
Synonyms	Pro-Leu-Gly-NHOH hydrochloride; L-Prolyl-L-leucyl-glycine hydroxamate hydrochloride; MMP Inhibitor I; Hydroxamoyl-Pro-Leu-Gly-OH hydrochloride; H-Pro-Leu-Gly-NHOH•HCl; PLG-NHOH•HCl; CAS 120928-08-7; Matrix Metalloproteinase Inhibitor Peptide
EINECS	Contact for details

Quality Control

Every batch of H-Pro-Leu-Gly-Nhoh Hcl is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are supplied with each shipment, detailing results from HPLC, NMR, and MS. Our quality commitment aligns with the standards expected for research-grade biochemicals, supporting reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -15°C to -25°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Tested in standard MMP inhibition assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.