Description

Linotroban is a potent and selective thromboxane A2 (TXA2) receptor antagonist, a key compound in cardiovascular and thrombosis research. Its primary value lies in its ability to block the pro-thrombotic and vasoconstrictive effects of TXA2, making it a critical research tool for studying platelet aggregation and vascular function. This product is essential for pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on developing novel antiplatelet and antithrombotic therapies.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies investigating thromboxane receptor-mediated pathways.
• Cardiovascular Disease Models: Applied in preclinical research for conditions like myocardial infarction, stroke, and atherosclerosis to understand and inhibit pathological platelet activation.
• Platelet Function Assays: Serves as a specific inhibitor in in vitro and ex vivo experiments to assess platelet aggregation and secretion.
• Drug Discovery & Development: A vital tool for screening and validating new antiplatelet drug candidates targeting the TXA2 receptor.
• Biochemical Studies: Utilized to elucidate the structure-activity relationship (SAR) of TXA2 receptor antagonists.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Linotroban
CAS No.	120824-08-0
Molecular Formula	C17H17N3O3S
Molecular Weight	343.40 g/mol
Synonyms	BMS 180,291; BMS-180291; BMS180291; Linotroban (BMS-180291); 4-[2-(4-Chlorobenzenesulfonamido)ethyl]phenoxyacetic Acid; [4-[2-[(4-Chlorophenyl)sulfonylamino]ethyl]phenoxy]acetic Acid; 1-[[(4-Chlorophenyl)sulfonyl]amino]-4-phenoxybutane-4-carboxylic Acid
EINECS	Contact for details

Quality Control

Our Linotroban CAS NO 120824-08-0 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.