Description

Methyl 1,3-Dimethyl-2,4-Dioxo-1,2,3,4-Tetrahydropyrido[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyridopyrimidine class of heterocyclic compounds. Its complex, multi-functional structure makes it a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral research. This compound is essential for medicinal chemistry R&D teams and process development scientists working on next-generation small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates targeting specific biological pathways.
• Oncology Research: Serves as a core scaffold for developing kinase inhibitors and other targeted cancer therapies due to its pyridopyrimidine structure.
• Antiviral Drug Development: Used in research programs aimed at creating novel antiviral agents, leveraging its heterocyclic framework.
• Medicinal Chemistry & SAR Studies: Employed for structure-activity relationship (SAR) exploration to optimize potency, selectivity, and pharmacokinetic properties of lead compounds.
• Process Chemistry & Scale-Up: Utilized in the development and optimization of robust, scalable synthetic routes for API manufacturing under cGMP conditions.
• Biochemical Tool Compound: Can be used to create probes for studying enzyme function and cellular signaling mechanisms in biological assays.

Basic Information

Product Name	Methyl 1,3-Dimethyl-2,4-Dioxo-1,2,3,4-Tetrahydropyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	120788-68-3
Molecular Formula	C12H13N3O4
Molecular Weight	263.25 g/mol
Synonyms	1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxylic acid methyl ester; Methyl 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxylate; 6-Methoxycarbonyl-1,3-dimethyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-2,4-dione; 1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxylate methyl ester; Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 1,3-Dimethyl-2,4-Dioxo-1,2,3,4-Tetrahydropyrido[2,3-D]Pyrimidine-6-Carboxylate adheres to stringent quality management systems, ensuring batch-to-batch consistency for research and development. Each lot is characterized and released with a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development projects with custom purity grades and specifications tailored to your synthetic route requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.