Description

2-Bromo-4-Chloro-5-Fluoro-Phenylamine is a halogenated aniline derivative serving as a versatile and critical building block in advanced organic synthesis. Its value lies in the strategic placement of bromine, chlorine, and fluorine atoms on the aromatic ring, which allows for selective functionalization and the introduction of unique physicochemical properties into target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the halogen pattern contributes to biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing complex, halogenated azo dyes and high-performance pigments.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig amination for carbon-carbon and carbon-heteroatom bond formation.
• Chemical Biology & Proteomics: Utilized as a building block for synthesizing molecular probes, affinity labels, and tags for studying biological systems.

Basic Information

Product Name	2-Bromo-4-Chloro-5-Fluoro-Phenylamine
CAS No.	120694-11-3
Molecular Formula	C6H4BrClFN
Molecular Weight	224.46 g/mol
Synonyms	2-Bromo-4-chloro-5-fluoroaniline; 1-Amino-2-bromo-4-chloro-5-fluorobenzene; 5-Fluoro-2-bromo-4-chloroaniline; Benzenamine, 2-bromo-4-chloro-5-fluoro-; (2-Bromo-4-chloro-5-fluorophenyl)amine; 2-Bromo-4-chloro-5-fluorobenzenamine
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Chloro-5-Fluoro-Phenylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its amine functionality and light sensitivity, prolonged exposure to air and light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	72 - 76 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.