Description

Fmoc-Gln(Tmob)-Oh is a protected amino acid derivative, specifically an Fmoc-protected glutamine side-chain protected with the Tmob (2,4,6-Trimethoxybenzyl) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity, reliable intermediates for peptide drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated, stepwise synthesis of peptides, particularly where glutamine incorporation is required.
• Pharmaceutical Research & Development: Used in the discovery and production of therapeutic peptides, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Bioconjugation and Peptide Labeling: Serves as a precursor for creating modified peptides with specific functional handles for labeling or coupling to other molecules.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic and Institutional Research: Fundamental reagent for studies in biochemistry, molecular biology, and medicinal chemistry focused on peptide structure and function.
• Custom Peptide Service Providers: A standard raw material for CROs and CDMOs offering bespoke peptide synthesis services to the global market.

Basic Information

Product Name	Fmoc-Gln(Tmob)-Oh
CAS No.	120658-64-2
Molecular Formula	C₃₀H₃₂N₂O₈
Molecular Weight	548.59 g/mol
Synonyms	Fmoc-Gln(Tmob)-OH; N-α-Fmoc-N-γ-(2,4,6-trimethoxybenzyl)-L-glutamine; Fmoc-L-glutamine(Tmob)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((2,4,6-trimethoxybenzyl)amino)-5-oxopentanoic acid; Fmoc-Glutamine(Tmob)-OH; Fmoc-Gln(Tmb)-OH; N-α-(9-Fluorenylmethoxycarbonyl)-N-γ-(2,4,6-trimethoxybenzyl)-L-glutamine
EINECS	Contact for details

Quality Control

Our Fmoc-Gln(Tmob)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.