Description

Fmoc-Asn(Tmob)-Oh is a protected amino acid derivative, specifically an N-α-Fmoc-protected asparagine with a Tmob (2,4,6-trimethoxybenzyl) side-chain protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent in the Fmoc-strategy for the sequential assembly of peptide chains.
• Pharmaceutical Research: Used in the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial R&D: Fundamental for biochemical studies involving protein structure, function, and interactions.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences.

Basic Information

Product Name	Fmoc-Asn(Tmob)-Oh
CAS No.	120658-63-1
Molecular Formula	C30H31NO8
Molecular Weight	533.57 g/mol
Synonyms	Fmoc-Asn(Tmob)-OH; N-α-Fmoc-N-γ-(2,4,6-trimethoxybenzyl)-L-asparagine; Fmoc-L-asparagine(Tmob)-OH; Fmoc-Asn(Tmb)-OH; (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[(2,4,6-trimethoxyphenyl)methoxy]-4-oxobutanoic acid; N-Fmoc-N'-Tmob-L-asparagine; Fmoc-Asn(2,4,6-MeOBzl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Asn(Tmob)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (argon/nitrogen) after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.