Description

(2S,5R)-5-(6-Iodo-9H-Purine-9-Yl)Tetrahydro-2-Furanmethanol is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound matters as a key chiral intermediate for synthesizing modified nucleotides and potential antiviral or anticancer agents, offering researchers precise control over stereochemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors working on novel therapeutic candidates and diagnostic probes.

Application

• Pharmaceutical Intermediate: Critical chiral building block for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Antiviral Research: Used in the development of potential therapeutic agents targeting viral polymerases and replication mechanisms.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Bioconjugation & Probe Development: The iodine moiety allows for further functionalization via cross-coupling reactions, useful for creating labeled probes for biochemical assays.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in universities and research institutes for studying enzyme mechanisms, nucleotide metabolism, and nucleic acid chemistry.

Basic Information

Product Name	(2S,5R)-5-(6-Iodo-9H-Purine-9-Yl)Tetrahydro-2-Furanmethanol
CAS No.	120503-37-9
Molecular Formula	C10H11IN4O2
Molecular Weight	346.12 g/mol
Synonyms	6-Iodo-9-[(2S,5R)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-9H-purine; (2S,5R)-5-(6-Iodo-9H-purin-9-yl)tetrahydro-2-furanmethanol; 6-Iodopurine nucleoside derivative; 9-[(2S,5R)-5-(Hydroxymethyl)tetrahydro-2-furanyl]-6-iodo-9H-purine; 6-Iodo-9-((2S,5R)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purine
EINECS	Contact for details

Quality Control

Our (2S,5R)-5-(6-Iodo-9H-Purine-9-Yl)Tetrahydro-2-Furanmethanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.