Description

(2S,5R)-5-(6-Chloro-9H-Purine-9-Yl)Tetrahydro-2-Furanmethanol is a high-purity nucleoside analogue intermediate of significant commercial and research interest. This compound is valued for its role as a key chiral building block in the synthesis of complex antiviral and anticancer pharmaceuticals. It is primarily required by pharmaceutical R&D laboratories, process development chemists, and manufacturers of active pharmaceutical ingredients (APIs) for nucleoside-based therapies.

Application

• Pharmaceutical Intermediate: Critical chiral precursor in the synthesis of antiviral and anticancer nucleoside analogues.
• Antiviral Drug Development: Used in research and production of potential therapeutics targeting viral polymerases.
• Oncology Research: Serves as a building block for novel chemotherapeutic agents that interfere with DNA/RNA synthesis.
• Process Chemistry: Employed in route scouting and scale-up for the manufacture of complex active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.
• Custom Synthesis: Starting material for the preparation of labeled compounds or specialized derivatives for structure-activity relationship (SAR) studies.

Basic Information

Product Name	(2S,5R)-5-(6-Chloro-9H-Purine-9-Yl)Tetrahydro-2-Furanmethanol
CAS No.	120503-34-6
Molecular Formula	C10H11ClN4O2
Molecular Weight	254.67 g/mol
Synonyms	(2S,5R)-5-(6-Chloro-9H-purin-9-yl)tetrahydro-2-furanmethanol; 6-Chloro-9-[(2S,5R)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-9H-purine; 6-Chloro-9-[(2S,5R)-5-(hydroxymethyl)tetrahydro-2-furanyl]-9H-purine; (2S,5R)-5-(6-Chloropurin-9-yl)tetrahydrofuran-2-methanol; 9-[(2S,5R)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]-6-chloro-9H-purine; 6-Chloro-9-(5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purine (cis isomer specified); cis-6-Chloro-9-(5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purine
EINECS	Contact for details

Quality Control

Our (2S,5R)-5-(6-Chloro-9H-Purine-9-Yl)Tetrahydro-2-Furanmethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storage under inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.